Corey R Hopkins Selected Research

metabotropic glutamate receptor 4

1/2016	Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).
1/2016	Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.
8/2015	Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist.
5/2012	Metabotropic glutamate receptor 4 (mGlu4)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature.
6/2009	mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.
1/2009	Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease.

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Corey R Hopkins Research Topics

Disease

16	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2009
7	Schizophrenia (Dementia Praecox) 06/2020 - 04/2010
7	Catalepsy 10/2019 - 11/2011
5	Neoplasms (Cancer) 04/2021 - 01/2016
4	Alzheimer Disease (Alzheimer's Disease) 01/2012 - 08/2010
3	Dyskinesias (Dyskinesia) 01/2022 - 08/2015
3	Pain (Aches) 05/2019 - 05/2012
3	Major Depressive Disorder (Major Depressive Disorders) 10/2011 - 10/2010
2	Proteinuria 01/2021 - 12/2017
2	Hypertension (High Blood Pressure) 10/2019 - 01/2018
2	Heart Failure 10/2019 - 01/2012
2	Renal Insufficiency (Renal Failure) 12/2013 - 01/2013
2	Seizures (Absence Seizure) 08/2012 - 07/2010
1	Bradycardia 12/2021
1	Colonic Neoplasms (Colon Cancer) 04/2021
1	Colorectal Neoplasms (Colorectal Cancer) 04/2021
1	Prostatic Neoplasms (Prostate Cancer) 01/2021
1	Nephrosis 01/2021
1	Diffuse Intrinsic Pontine Glioma 01/2020
1	Cocaine-Related Disorders (Cocaine Addiction) 01/2020
1	Myositis Ossificans (Fibrodysplasia Ossificans Progressiva) 01/2020
1	Hypotension (Low Blood Pressure) 10/2019
1	Cardiac Arrhythmias (Arrythmia) 01/2019
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	SeSAME syndrome 01/2018
1	Epilepsy (Aura) 01/2018
1	Deafness (Deaf Mutism) 01/2018
1	Ataxia (Dyssynergia) 01/2018
1	Kidney Diseases (Kidney Disease) 12/2017
1	Neurodevelopmental Disorders 01/2017
1	Rett Syndrome (Rett's Disorder) 01/2017
1	Malaria 11/2016
1	Mosquito-Borne Diseases 11/2016
1	Skin Diseases (Skin Disease) 10/2016
1	Anemia 10/2016
1	Atherosclerosis 10/2016
1	Carcinogenesis 01/2016
1	Astrocytoma (Pilocytic Astrocytoma) 01/2016
1	Glioma (Gliomas) 01/2016
1	Chronic Pain 01/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2013
1	Cardiotoxicity 11/2012
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 11/2012
1	Neuroinflammatory Diseases 05/2012

Drug/Important Bio-Agent (IBA)

7	Haloperidol (Haldol)FDA LinkGeneric 10/2019 - 11/2011
6	metabotropic glutamate receptor 4IBA 01/2016 - 01/2009
4	Levodopa (L Dopa)FDA LinkGeneric 01/2022 - 02/2012
4	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 08/2015 - 01/2009
4	Pharmaceutical PreparationsIBA 11/2012 - 09/2010
2	AC1903IBA 01/2021 - 12/2017
2	PPAR gammaIBA 01/2021 - 11/2006
2	Phosphotransferases (Kinase)IBA 01/2020 - 01/2016
2	SaltsIBA 10/2019 - 01/2018
2	DiureticsIBA 10/2019 - 01/2018
2	Morphine (MS Contin)FDA LinkGeneric 05/2019 - 01/2019
2	Analgesics (Analgesic Drugs)IBA 05/2019 - 01/2019
2	VU0466551IBA 05/2019 - 01/2019
2	benzocycloheptapyridineIBA 01/2018 - 01/2013
2	LigandsIBA 01/2017 - 01/2015
2	InsecticidesIBA 11/2016 - 01/2013
2	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 10/2016 - 01/2016
2	N-(3-chlorophenyl)picolinamideIBA 08/2015 - 02/2012
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 06/2011 - 08/2010
2	Serotonin (5 Hydroxytryptamine)IBA 06/2010 - 05/2010
1	Carbachol (Carbastat)FDA Link 12/2021
1	Fluorouracil (Carac)FDA LinkGeneric 04/2021
1	Biological ProductsIBA 01/2021
1	Cytoskeletal ProteinsIBA 01/2021
1	Puromycin AminonucleosideIBA 01/2021
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 06/2020
1	dipinacoline glutamateIBA 01/2020
1	Cocaine (Cocaine HCl)IBA 01/2020
1	Phosphodiesterase 4 InhibitorsIBA 01/2020
1	VU0652957IBA 03/2019
1	Opioid Analgesics (Opioids)IBA 01/2019
1	Opioid Receptors (Opioid Receptor)IBA 01/2019
1	GTP-Binding Proteins (G-Protein)IBA 01/2019
1	AminesIBA 01/2018
1	Ion Channels (Ion Channel)IBA 12/2017
1	Biogenic Amines (Biogenic Amine)IBA 01/2017
1	Methyl-CpG-Binding Protein 2IBA 01/2017
1	Dopamine AntagonistsIBA 12/2016
1	Inwardly Rectifying Potassium Channels (Inward Rectifier Potassium Channels)IBA 11/2016
1	Bone Morphogenetic Protein ReceptorsIBA 01/2016
1	gamma-Aminobutyric Acid (GABA)IBA 08/2015
1	Glutamic Acid (Glutamate)FDA Link 08/2015
1	Dihydroxyphenylalanine (Dopa)IBA 08/2015
1	LSP1 2111IBA 08/2015
1	bovine adrenal medulla 8-22IBA 01/2015
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2015
1	Peptides (Polypeptides)IBA 01/2015
1	AlbuminsIBA 12/2013
1	ML253IBA 01/2013
1	Potassium Channels (Potassium Channel)IBA 01/2013
1	Ether (Diethyl Ether)IBA 11/2012
1	ezogabine (retigabine)IBA 08/2012
1	Glutamate Receptors (Glutamate Receptor)IBA 05/2012
1	2- (2- furanyl)- 7- (2- (4- (4- (2- methoxyethoxy)phenyl)- 1- piperazinyl)ethyl)- 7H- pyrazolo(4,3- e)(1,2,4)triazolo(1,5- c)pyrimidine- 5- amineIBA 02/2012

Therapy/Procedure

6	Therapeutics 04/2021 - 06/2009
1	Drug Therapy (Chemotherapy) 04/2021